Commerce and trade have been part of Pearl-Meigs-Monroe since Rochesterville's younger days, as omnibus companies and later trolleys operated daily runs from downtown to Pittsford Village down Monroe Ave, creating an urban retail center much like South Wedge and Park Ave. This history is represented in the horse hair color of the work-horse and barge graphic.

But perhaps the biggest part of Pearl-Meigs-Monroe's Commerce/trade background is its being situated on the banks of, at its inception, the largest commercial trade route in the country: the Erie Canal. Horse and mule pulled mammoth barges (chosen as the graphic for the shirt) loaded with a variety of cargo from Albany to Buffalo and back again, connecting major cities with a dedicated waterway.

The medical blue color of the shirt helps represent the work of Dr. Charles Sumner, leading advocate for the homeopathic approach to medicine in Rochester. His advocation also led to the creation of the Rochester Homeopathic Hospital, which over time would become the Genesee Hospital. There is a quiet residential street in the Lock 66 pocket neighborhood of Pearl-Meigs-Monroe and park that splits the street both named for Sumner.

The Rochester subway system traveled west to east servicing as much of the city neighborhoods as possible: Residents and visitors of Pearl-Meigs-Monroe would primarily jump on and off the Meigs And Goodman station for access.